Nasal Polyps Natural Treatment ( New Study )

In recent study, Nasal polyp tissue was obtained from patients undergoing nasal polypectomies and bronchial tissue was dissected from macroscopically normal parts of human lungs derived from patients undergoing surgery due to lung carcinoma. The tissues were collected within 30 min after surgical removal, kept on ice, chopped with fine scissors and carefully rinsed several times in ice-cold phosphate- buffered saline (PBS (pH 7.4), 0.9 mM Ca2+) until the buffer was macroscopically free of contaminating blood.

Incubation of chopped nasal polyps without exogenous stimulus at 37°C for 30 min, led to production of 15-HETE, while no 12- or 5-HETE was formed. Ad¬dition of arachidonic acid (75 ^M) markedly increased the 15-HETE synthesis and induced a minor 12-HETE production. Addition of calcium ionophore A23187 did not significantly alter the HETE formation. Detectable levels of 5-HETE could not be observed under any condition. Bronchial tissue converted exogenous arachidonic acid to 15-HETE, while 5- and 12-HETE was not formed. Comparison of the synthetic capacity showed that bronchial tissue pro-duced 7.5 ± 5.3 nmol 15-HETE/g tissue (mean ± SD, n = 4) and polyp tissue 37.0 ± 18.4 nmol/g (n = 3) after incubation with arachidonic acid and ionophore A23187

This study demonstrate that human nasal polyps possess considerable 15-lipoxygenase ac-tivity and a capacity to transform authentic or granulocyte-derived LTA4 to lipoxins. Using natural method will the next steps on Nasal polyps treatment

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